Estrogen enhances the bone regeneration potential of periodontal ligament stem cells derived from osteoporotic rats and seeded on nano-hydroxyapatite/collagen/poly(L-lactide)
Identifieur interne : 000848 ( Main/Exploration ); précédent : 000847; suivant : 000849Estrogen enhances the bone regeneration potential of periodontal ligament stem cells derived from osteoporotic rats and seeded on nano-hydroxyapatite/collagen/poly(L-lactide)
Auteurs : Ling-Ling E [République populaire de Chine] ; Wen-Huan Xu [République populaire de Chine] ; Lin Feng [République populaire de Chine] ; Yi Liu [République populaire de Chine] ; Dong-Qing Cai [République populaire de Chine] ; Ning Wen [République populaire de Chine] ; Wen-Jie Zheng [République populaire de Chine]Source :
- International Journal of Molecular Medicine [ 1107-3756 ] ; 2016.
Abstract
This study investigated the effects of estrogen on the bone regeneration potential of periodontal ligament stem cells (PDLSCs) derived from osteoporotic rats and seeded on a collagen-based composite scaffold [nano-hydroxyapatite/collagen/poly(L-lactide) (nHAC/PLA)]. For this purpose, 48 healthy 3-month-old Sprague-Dawley female rats were divided into 2 groups as follows: the bilaterally ovariectomized (OVX) rats and sham-operated rats. The PDLSCs were isolated at 3 months after surgery (by which time postmenopausal osteoporosis had developed). The effects of estrogen on the characteristics of these cells seeded in a culture plate and of the cells seeded on nHAC/PLA were then investigated. The PDLSC + nHAC/PLA constructs were implanted subcutaneously into the backs of severe combined immunodeficient (SCID) mice for 12 weeks in order to examine the role of estrogen in the bone formation ability of PDLSCs derived from osteoporotic rats. The results from methyl thiazolyl tetrazolium (MTT) assay revealed that the proliferation of the cells derived from the rats in the OVX group was significantly higher than that of the cells derived from the rats in the sham-operated group at the stage of logarithmic growth. The staining intensity of alkaline phosphatase (ALP) and the mineralization of the cells derived from the rats in the OVX group was significantly weaker than that of the cells from the rats in the sham-operated group. When the PDLSCs were seeded on nHAC/PLA, ALP activity, osteocalcin (OCN) secretion, mineral formation and the mRNA expression levels of ALP, OCN, estrogen receptor (ER)α and ERβ in the cells derived from the rats in the OVX group were markedly decreased. Treatment with 17β-estradiol (E2) significantly weakened the proliferative ability of the cells derived from the OVX group rats, and enhanced their osteogenic differentiation ability and the mRNA expression levels of ALP, OCN, ERα and ERβ. When the constructs were implanted into the backs of SCID mice for 12 weeks, the results of histological analysis indicated that the constructs derived from the OVX group rats had a few newly formed bones and osteoids; however, a great number of newly formed bones and osteoids were present in the ones from the sham-operated group and the OVX + E2 group rats. Our findings further indicate that estrogen deficiency impairs the osteogenic differentiation potential of PDLSCs, and that ER plays an important role in the bone regeneration ability of PDLSCs. Estrogen enhances the bone regeneration potential of PDLSCs derived from osteoporotic rats and seeded on nHAC/PLA. This study may provide insight into the clinical management of periodontal bone tissue repair in postmenopausal women with the use of estrogen-mediated PDLSCs seeded on nHAC/PLA.
Url:
DOI: 10.3892/ijmm.2016.2559
PubMed: 27082697
PubMed Central: 4866970
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Wen Huan" sort="Xu, Wen Huan" uniqKey="Xu W" first="Wen-Huan" last="Xu">Wen-Huan Xu</name><affiliation wicri:level="1"><nlm:aff id="af2-ijmm-37-06-1475">Scientific Research Department, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Scientific Research Department, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><affiliation wicri:level="1"><nlm:aff id="af1-ijmm-37-06-1475">Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name><affiliation wicri:level="1"><nlm:aff id="af1-ijmm-37-06-1475">Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cai, Dong Qing" sort="Cai, Dong Qing" uniqKey="Cai D" first="Dong-Qing" last="Cai">Dong-Qing Cai</name><affiliation wicri:level="1"><nlm:aff id="af3-ijmm-37-06-1475">Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632</wicri:regionArea><wicri:noRegion>Guangdong 510632</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Ning" sort="Wen, Ning" uniqKey="Wen N" first="Ning" last="Wen">Ning Wen</name><affiliation wicri:level="1"><nlm:aff id="af1-ijmm-37-06-1475">Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Stomatology, Medical Administrative Division, Chinese PLA General Hospital, Beijing 100853</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zheng, Wen Jie" sort="Zheng, Wen Jie" uniqKey="Zheng W" first="Wen-Jie" last="Zheng">Wen-Jie Zheng</name><affiliation wicri:level="1"><nlm:aff id="af3-ijmm-37-06-1475">Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632</wicri:regionArea><wicri:noRegion>Guangdong 510632</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Molecular Medicine</title><idno type="ISSN">1107-3756</idno><idno type="eISSN">1791-244X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study investigated the effects of estrogen on the bone regeneration potential of periodontal ligament stem cells (PDLSCs) derived from osteoporotic rats and seeded on a collagen-based composite scaffold [nano-hydroxyapatite/collagen/poly(L-lactide) (nHAC/PLA)]. For this purpose, 48 healthy 3-month-old Sprague-Dawley female rats were divided into 2 groups as follows: the bilaterally ovariectomized (OVX) rats and sham-operated rats. The PDLSCs were isolated at 3 months after surgery (by which time postmenopausal osteoporosis had developed). The effects of estrogen on the characteristics of these cells seeded in a culture plate and of the cells seeded on nHAC/PLA were then investigated. The PDLSC + nHAC/PLA constructs were implanted subcutaneously into the backs of severe combined immunodeficient (SCID) mice for 12 weeks in order to examine the role of estrogen in the bone formation ability of PDLSCs derived from osteoporotic rats. The results from methyl thiazolyl tetrazolium (MTT) assay revealed that the proliferation of the cells derived from the rats in the OVX group was significantly higher than that of the cells derived from the rats in the sham-operated group at the stage of logarithmic growth. The staining intensity of alkaline phosphatase (ALP) and the mineralization of the cells derived from the rats in the OVX group was significantly weaker than that of the cells from the rats in the sham-operated group. When the PDLSCs were seeded on nHAC/PLA, ALP activity, osteocalcin (OCN) secretion, mineral formation and the mRNA expression levels of ALP, OCN, estrogen receptor (ER)α and ERβ in the cells derived from the rats in the OVX group were markedly decreased. Treatment with 17β-estradiol (E2) significantly weakened the proliferative ability of the cells derived from the OVX group rats, and enhanced their osteogenic differentiation ability and the mRNA expression levels of ALP, OCN, ERα and ERβ. When the constructs were implanted into the backs of SCID mice for 12 weeks, the results of histological analysis indicated that the constructs derived from the OVX group rats had a few newly formed bones and osteoids; however, a great number of newly formed bones and osteoids were present in the ones from the sham-operated group and the OVX + E2 group rats. Our findings further indicate that estrogen deficiency impairs the osteogenic differentiation potential of PDLSCs, and that ER plays an important role in the bone regeneration ability of PDLSCs. Estrogen enhances the bone regeneration potential of PDLSCs derived from osteoporotic rats and seeded on nHAC/PLA. This study may provide insight into the clinical management of periodontal bone tissue repair in postmenopausal women with the use of estrogen-mediated PDLSCs seeded on nHAC/PLA.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bertonazzi, A" uniqKey="Bertonazzi A">A Bertonazzi</name></author><author><name sortKey="Nelson, B" uniqKey="Nelson B">B Nelson</name></author><author><name sortKey="Salvador, J" uniqKey="Salvador J">J Salvador</name></author><author><name sortKey="Umland, E" uniqKey="Umland E">E Umland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniell, Hw" uniqKey="Daniell H">HW Daniell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tominari, T" uniqKey="Tominari T">T Tominari</name></author><author><name sortKey="Hirata, M" uniqKey="Hirata M">M Hirata</name></author><author><name sortKey="Matsumoto, C" uniqKey="Matsumoto C">C 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sortKey="Trimova, R" uniqKey="Trimova R">R Trimova</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="E, Ling Ling" sort="E, Ling Ling" uniqKey="E L" first="Ling-Ling" last="E">Ling-Ling E</name></noRegion><name sortKey="Cai, Dong Qing" sort="Cai, Dong Qing" uniqKey="Cai D" first="Dong-Qing" last="Cai">Dong-Qing Cai</name><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name><name sortKey="Wen, Ning" sort="Wen, Ning" uniqKey="Wen N" first="Ning" last="Wen">Ning Wen</name><name sortKey="Xu, Wen Huan" sort="Xu, Wen Huan" uniqKey="Xu W" first="Wen-Huan" last="Xu">Wen-Huan Xu</name><name sortKey="Zheng, Wen Jie" sort="Zheng, Wen Jie" 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